Ontology highlight
ABSTRACT:
SUBMITTER: Hao F
PROVIDER: S-EPMC7672455 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nucleic acids research 20201101 20
Linker histones (H1s) are key structural components of the chromatin of higher eukaryotes. However, the mechanisms by which the intrinsically disordered linker histone carboxy-terminal domain (H1 CTD) influences chromatin structure and gene regulation remain unclear. We previously demonstrated that the CTD of H1.0 undergoes a significant condensation (reduction of end-to-end distance) upon binding to nucleosomes, consistent with a transition to an ordered structure or ensemble of structures. Her ...[more]