Ontology highlight
ABSTRACT:
SUBMITTER: Sartori F
PROVIDER: S-EPMC7672524 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Sartori Fabio F Hafner Anne-Sophie AS Karimi Ali A Nold Andreas A Fonkeu Yombe Y Schuman Erin M EM Tchumatchenko Tatjana T
Cell reports 20201101 7
Across their dendritic trees, neurons distribute thousands of protein species that are necessary for maintaining synaptic function and plasticity and that need to be produced continuously and trafficked to their final destination. As each dendritic branchpoint splits the protein flow, increasing branchpoints decreases the total protein number downstream. Consequently, a neuron needs to produce more proteins to maintain a minimal protein number at distal synapses. Combining in vitro experiments a ...[more]