Ontology highlight
ABSTRACT:
SUBMITTER: Pavlovic N
PROVIDER: S-EPMC7672568 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20201031 21
The P2Y12 receptor is an adenosine diphosphate responsive G protein-coupled receptor expressed on the surface of platelets and is the pharmacologic target of several anti-thrombotic agents. In this study, we use liver samples from mice with cirrhosis and hepatocellular carcinoma to show that P2Y12 is expressed by macrophages in the liver. Using in vitro methods, we show that inhibition of P2Y12 with ticagrelor enhances tumor cell phagocytosis by macrophages and induces an anti-tumoral phenotype. ...[more]