Ontology highlight
ABSTRACT:
SUBMITTER: Okuyama T
PROVIDER: S-EPMC7672621 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Okuyama Tomoko T Shirakawa Jun J Tajima Kazuki K Ino Yoko Y Vethe Heidrun H Togashi Yu Y Kyohara Mayu M Inoue Ryota R Miyashita Daisuke D Li Jinghe J Goto Nozomi N Ichikawa Taiga T Yamasaki Shingo S Ohnuma Haruka H Takayanagi Rie R Kimura Yayoi Y Hirano Hisashi H Terauchi Yasuo Y
International journal of molecular sciences 20201022 21
Abnormal hepatic insulin signaling is a cause or consequence of hepatic steatosis. DPP-4 inhibitors might be protective against fatty liver. We previously reported that the systemic inhibition of insulin receptor (IR) and IGF-1 receptor (IGF1R) by the administration of OSI-906 (linsitinib), a dual IR/IGF1R inhibitor, induced glucose intolerance, hepatic steatosis, and lipoatrophy in mice. In the present study, we investigated the effects of a DPP-4 inhibitor, linagliptin, on hepatic steatosis in ...[more]