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Immune suppression in the early stage of COVID-19 disease.

ABSTRACT: The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients. We propose a two-stage mechanism of pathogenesis for this unusual viral infection. Our data advance our understanding of the clinical features of COVID-19 infections and provide a resource for future mechanistic and therapeutics studies.

SUBMITTER: Tian W

PROVIDER: S-EPMC7673112 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Immune suppression in the early stage of COVID-19 disease.

Tian Wenmin W Zhang Nan N Jin Ronghua R Feng Yingmei Y Wang Siyuan S Gao Shuaixin S Gao Ruqin R Wu Guizhen G Tian Di D Tan Wenjie W Chen Yang Y Gao George Fu GF Wong Catherine C L CCL

Nature communications 20201117 1

The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and sever ...[more]

PMID: 33203833

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