Ontology highlight
ABSTRACT:
SUBMITTER: Brown RJP
PROVIDER: S-EPMC7673688 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Brown Richard J P RJP Tegtmeyer Birthe B Sheldon Julie J Khera Tanvi T Anggakusuma Todt Daniel D Vieyres Gabrielle G Weller Romy R Joecks Sebastian S Zhang Yudi Y Sake Svenja S Bankwitz Dorothea D Welsch Kathrin K Ginkel Corinne C Engelmann Michael M Gerold Gisa G Steinmann Eike E Yuan Qinggong Q Ott Michael M Vondran Florian W R FWR Krey Thomas T Ströh Luisa J LJ Miskey Csaba C Ivics Zoltán Z Herder Vanessa V Baumgärtner Wolfgang W Lauber Chris C Seifert Michael M Tarr Alexander W AW McClure C Patrick CP Randall Glenn G Baktash Yasmine Y Ploss Alexander A Thi Viet Loan Dao VLD Michailidis Eleftherios E Saeed Mohsan M Verhoye Lieven L Meuleman Philip P Goedecke Natascha N Wirth Dagmar D Rice Charles M CM Pietschmann Thomas T
Science advances 20201104 45
Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate species barrier determinants limiting infection of rodents, murine liver complementary DNA library screening was performed, identifying transmembrane proteins Cd302 and Cr1l as potent restrictors of HCV propagation. Combined ectopic expression in human hepatoma cells impeded HCV uptake and cooperatively mediated transcriptional dysregulation of a noncanonical program of immunity genes. Murine hepatocyte expres ...[more]