Ontology highlight
ABSTRACT:
SUBMITTER: Xin X
PROVIDER: S-EPMC7673723 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Xin Xiaofei X Kumar Virender V Lin Feng F Kumar Vinod V Bhattarai Rajan R Bhatt Vijaya R VR Tan Chalet C Mahato Ram I RI
Science advances 20201111 46
Desmoplastic and hypoxic pancreatic cancer microenvironment induces aberrant expression of miRNAs and hypoxia-inducible factor-1α (HIF-1α) responsible for gemcitabine (GEM) resistance. We demonstrated that miR-519c was down-regulated in pancreatic cancer and transfection of miR-519c in GEM-resistant pancreatic cancer cells inhibited HIF-1α level under hypoxia. We synthesized redox-sensitive mPEG-<i>co</i>-P(Asp)-<i>g</i>-DC-<i>g</i>-S-S-GEM polymer, with GEM payload of 14% (w/w) and 90% GEM rele ...[more]