Ontology highlight
ABSTRACT:
SUBMITTER: Rivers E
PROVIDER: S-EPMC7673780 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Rivers Elizabeth E Rai Rajeev R Lötscher Jonas J Hollinshead Michael M Markelj Gasper G Thaventhiran James J Worth Austen A Cavazza Alessia A Hess Christoph C Bajaj-Elliott Mona M Thrasher Adrian J AJ
eLife 20201102
The actin cytoskeletal regulator Wiskott Aldrich syndrome protein (WASp) has been implicated in maintenance of the autophagy-inflammasome axis in innate murine immune cells. Here, we show that WASp deficiency is associated with impaired rapamycin-induced autophagosome formation and trafficking to lysosomes in primary human monocyte-derived macrophages (MDMs). WASp reconstitution in vitro and in WAS patients following clinical gene therapy restores autophagic flux and is dependent on the actin-re ...[more]