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Synthesis and cytotoxic analysis of thiolated xylose derivatives decorated on gold nanoparticles.

ABSTRACT: The rapid development of metal nanoparticles capped by an organic monolayer offers the possibility to create a whole new variety of products with novel characteristic, functions and applications. Among these, nanoparticles covered with carbohydrates (glyconanoparticles) constitute a good bio-mimetic model of carbohydrate presentation at the cell surface and are currently centered on many glycobiological and biomedical applications. In this study, a series of novel D-xylose gold nanoparticles (AuNPs) with linkages of alkyl or polyethylene glycol have been synthesized via D-xylosethiols, forming self-assembled monolayers on gold nanoparticles. The nano-gold solution, two carbohydrate derivatives and modified nano-gold solution were tested for cytotoxicity to check the biocompatibility. The MTT assay on NIH 3T3 cell lines confirmed that all the test materials showed no toxicity with the more than 90 % of cell viability in both low concentration (1 ?M) and high concentration (100 ?M), compared with the control.

SUBMITTER: Shiue A

PROVIDER: S-EPMC7674290 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Synthesis and cytotoxic analysis of thiolated xylose derivatives decorated on gold nanoparticles.

Shiue Angus A Chen Jenn-Han JH Chang Chia-Ying CY Chang Shu-Mei SM Hwa Kuo-Yuan KY Chin Kai-Yen KY Leggett Graham G

Biotechnology reports (Amsterdam, Netherlands) 20201101

The rapid development of metal nanoparticles capped by an organic monolayer offers the possibility to create a whole new variety of products with novel characteristic, functions and applications. Among these, nanoparticles covered with carbohydrates (glyconanoparticles) constitute a good bio-mimetic model of carbohydrate presentation at the cell surface and are currently centered on many glycobiological and biomedical applications. In this study, a series of novel D-xylose gold nanoparticles (Au ...[more]

PMID: 33240795

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Dataset Information

Synthesis and cytotoxic analysis of thiolated xylose derivatives decorated on gold nanoparticles.

Publications

Synthesis and cytotoxic analysis of thiolated xylose derivatives decorated on gold nanoparticles.

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