Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
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ABSTRACT:
SUBMITTER: Park M
PROVIDER: S-EPMC7674384 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Park Min M Nishimura Takanori T Baeza-Garza Carlos D CD Caldwell Stuart T ST Pun Pamela Boon Li PBL Prag Hiran A HA Young Tim T Sauchanka Olga O Logan Angela A Forkink Marleen M Gruszczyk Anja V AV Prime Tracy A TA Arndt Sabine S Naudi Alba A Pamplona Reinald R Coughlan Melinda T MT Tate Mitchel M Ritchie Rebecca H RH Caicci Federico F Kaludercic Nina N Di Lisa Fabio F Smith Robin A J RAJ Hartley Richard C RC Murphy Michael P MP Krieg Thomas T
Cardiovascular drugs and therapy 20200926 6
<h4>Purpose</h4>HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and used it to confirm the therapeutic efficacy of the mitochondria-targeted dicarbonyl scavenger, MitoGamide.<h4>Methods and results</h4>A longitudinal echocardiographic analysis confirmed that Akita mice develop diastolic dysfunction with reduced E peak velocity, E/A ratio an ...[more]
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