Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota.
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ABSTRACT:
SUBMITTER: Ishida S
PROVIDER: S-EPMC7674416 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota.
Ishida Sachiko S Kato Kumiko K Tanaka Masami M Odamaki Toshitaka T Kubo Ryuichi R Mitsuyama Eri E Xiao Jin-Zhong JZ Yamaguchi Rui R Uematsu Satoshi S Imoto Seiya S Miyano Satoru S
Communications biology 20201118 1
Numerous host extrinsic and intrinsic factors affect the gut microbiota composition, but their cumulative effects do not sufficiently explain the variation in the microbiota, suggesting contributions of missing factors. The Japanese population possesses homogeneous genetic features suitable for genome-wide association study (GWAS). Here, we performed GWASs for human gut microbiota using 1068 healthy Japanese adults. To precisely evaluate genetic effects, we corrected for the impacts of numerous ...[more]
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