Ontology highlight
ABSTRACT:
SUBMITTER: Karnan S
PROVIDER: S-EPMC7674463 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Karnan Sivasundaram S Ota Akinobu A Murakami Hideki H Rahman Md Lutfur ML Hasan Muhammad Nazmul MN Wahiduzzaman Md M Hanamura Ichiro I Quang Vu Lam L Inoko Akihito A Hyodo Toshinori T Konishi Hiroyuki H Tsuzuki Shinobu S Hosokawa Yoshitaka Y
Cell death discovery 20201118 1
Malignant pleural mesothelioma (MPM) is an aggressive malignancy of the pleura that is currently incurable due to the lack of an effective early diagnostic method and specific medication. The CDKN2A (p16) and NF2 genes are both frequently mutated in MPM. To understand how these mutations contribute to MPM tumor growth, we generated NF2/p16 double-knockout (DKO) cell clones using human MeT-5A and HOMC-B1 mesothelial cell lines. Cell growth and migration activities were significantly increased in ...[more]