Ontology highlight
ABSTRACT:
SUBMITTER: Negwer M
PROVIDER: S-EPMC7674571 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Negwer Moritz M Piera Karol K Hesen Rick R Lütje Lukas L Aarts Lynn L Schubert Dirk D Nadif Kasri Nael N
Brain structure & function 20200925 9
Mutations in the Euchromatic Histone Methyltransferase 1 (EHMT1) gene cause Kleefstra syndrome, a rare form of intellectual disability (ID) with strong autistic traits and sensory processing deficits. Proper development of inhibitory interneurons is crucial for sensory function. Here we report a timeline of Parvalbumin-positive (PV<sup>+</sup>) interneuron development in the three most important sensory cortical areas in the Ehmt1<sup>+/-</sup> mouse. We find a hitherto unreported delay of PV<su ...[more]