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FGFR3 Alterations in the Era of Immunotherapy for Urothelial Bladder Cancer.


ABSTRACT: FGFR3 is a prognostic and predictive marker and is a validated therapeutic target in urothelial bladder cancer. Its utility as a marker and target in the context of immunotherapy is incompletely understood. We review the role of FGFR3 in bladder cancer and discuss preclinical and clinical clues of its effectiveness as a patient selection factor and therapeutic target in the era of immunotherapy.

SUBMITTER: Kacew A 

PROVIDER: S-EPMC7674585 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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<i>FGFR3</i> Alterations in the Era of Immunotherapy for Urothelial Bladder Cancer.

Kacew Alec A   Sweis Randy F RF  

Frontiers in immunology 20201105


<i>FGFR3</i> is a prognostic and predictive marker and is a validated therapeutic target in urothelial bladder cancer. Its utility as a marker and target in the context of immunotherapy is incompletely understood. We review the role of <i>FGFR3</i> in bladder cancer and discuss preclinical and clinical clues of its effectiveness as a patient selection factor and therapeutic target in the era of immunotherapy. ...[more]

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