Ontology highlight
ABSTRACT:
SUBMITTER: Tuominen I
PROVIDER: S-EPMC7674618 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Tuominen Iina I Fuqua Brie K BK Pan Calvin C Renaud Nicole N Wroblewski Kevin K Civelek Mete M Clerkin Kara K Asaryan Ashot A Haroutunian Sara G SG Loureiro Joseph J Borawski Jason J Roma Guglielmo G Knehr Judith J Carbone Walter W French Samuel S Parks Brian W BW Hui Simon T ST Mehrabian Margarete M Magyar Clara C Cantor Rita M RM Ukomadu Chinweike C Lusis Aldons J AJ Beaven Simon W SW
Cellular and molecular gastroenterology and hepatology 20200828 1
<h4>Background & aims</h4>Liver fibrosis is a multifactorial trait that develops in response to chronic liver injury. Our aim was to characterize the genetic architecture of carbon tetrachloride (CCl<sub>4</sub>)-induced liver fibrosis using the Hybrid Mouse Diversity Panel, a panel of more than 100 genetically distinct mouse strains optimized for genome-wide association studies and systems genetics.<h4>Methods</h4>Chronic liver injury was induced by CCl<sub>4</sub> injections twice weekly for 6 ...[more]