Ontology highlight
ABSTRACT:
SUBMITTER: Samra B
PROVIDER: S-EPMC7675064 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Samra Bachar B Konopleva Marina M Isidori Alessandro A Daver Naval N DiNardo Courtney C
Frontiers in oncology 20201105
The past decade has witnessed major advances in our understanding of molecular biology, which led to breakthrough novel therapies, importantly including the B-cell lymphoma-2 (BCL-2) inhibitor venetoclax. Notably, venetoclax-based combinations have improved outcomes, including both remission rates and overall survival, of older patients with acute myeloid leukemia (AML) deemed "unfit" for intensive chemotherapy due to age or comorbidities. This has translated into a rapid and widespread use of v ...[more]