Liver background uptake of [¹⁸F]FLT in PET imaging.

ABSTRACT: High liver uptake presents a problem for 3'-deoxy-3'-[¹⁸F]fluorothymidine ([¹⁸F]FLT) as a radiotracer for imaging cellular proliferation in the liver with positron emission tomography (PET). This investigation re-visited some issues related to the high liver background uptake of [¹⁸F]FLT with an animal model of woodchucks. Several enzymes involved in the hepatic catabolism of FLT, thymidine phosphorylase (TP, TYMP), uridine 5'-diphospho-glucuronosyl-transferases (UDP-GTs, short for UGTs), and β-glucuronidase (GUSB), their homology as well as hepatic expression between the human and the woodchuck was examined. Inhibitors of these enzymes, TP inhibitor (TPI) tipiracil hydrochloride, UGT inhibitor probenecid, β-glucuronidase inhibitor L-aspartate, were adminis

SUBMITTER: Sergeeva O 

PROVIDER: S-EPMC7675117 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature