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Design, Synthesis, Antiproliferative Evaluation, and Molecular Docking Studies of N-(3-Hydroxyindole)-Appended ?-Carbolines/Tetrahydro-?-Carbolines Targeting Triple-Negative and Non-Triple-Negative Breast Cancer.

ABSTRACT: The present manuscript pertains to the design and synthesis of a series of 3-hydroxyindole-substituted ?-carbolines/tetrahydro-?-carbolines with an aim to explore their antiproliferative structure-activity relationship against breast cancer. The conjugate with an optimum combination of a flexible tetrahydro-?-carboline core, a tertiary alcoholic group along with a chloro substituent on the indole ring, proved to be the most active compound. It displayed IC50 values of 13.61 and 22.76 ?M against MCF-7 (ER+) and MDA-MB-231 (ER-) cells, respectively. The docking studies were found to be consistent with experimental results owing to the stronger binding affinity of the synthesized conjugates via hydrophobic and H-bonding interactions.

SUBMITTER: Sharma B 

PROVIDER: S-EPMC7675558 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Design, Synthesis, Antiproliferative Evaluation, and Molecular Docking Studies of <i>N</i>-(3-Hydroxyindole)-Appended β-Carbolines/Tetrahydro-β-Carbolines Targeting Triple-Negative and Non-Triple-Negative Breast Cancer.

Sharma Bharvi B   Saha Sourav Taru ST   Perumal Shanen S   Gu Liang L   Ebenezer Oluwakemi O   Singh Parvesh P   Kaur Mandeep M   Kumar Vipan V  

ACS omega 20201105 45

The present manuscript pertains to the design and synthesis of a series of 3-hydroxyindole-substituted β-carbolines/tetrahydro-β-carbolines with an aim to explore their antiproliferative structure-activity relationship against breast cancer. The conjugate with an optimum combination of a flexible tetrahydro-β-carboline core, a tertiary alcoholic group along with a chloro substituent on the indole ring, proved to be the most active compound. It displayed IC<sub>50</sub> values of 13.61 and 22.76  ...[more]

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