The value of circulating long non-coding RNA maternally expressed gene 3 as a predictor of higher acute respiratory distress syndrome risk and 28-day mortality in sepsis patients.

ABSTRACT:

Objective

This study was to evaluate the potential of long non-coding RNA maternally expressed gene 3 (lncRNA MEG3) in predicting acute respiratory distress syndrome (ARDS) risk and its correlation with prognosis in sepsis patients.

Methods

The plasma samples were obtained from 112 sepsis patients within 24 hours after admission and 100 healthy controls (HCs) at enrollment. The lncRNA MEG3 expression in plasma samples was determined by RT-qPCR. In sepsis patients, ARDS occurrence was assessed based on Berlin definition of ARDS and 28-day mortality risk was evaluated.

Results

LncRNA MEG3 expression was increased in sepsis patients compared with HCs. During 28-day duration, 30 sepsis patients occurred ARDS and 82 sepsis patients did not occur ARDS. LncRNA MEG3 expressio

SUBMITTER: Wu X 

PROVIDER: S-EPMC7676220 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature