Association of Pre- and Posttreatment Neutrophil-Lymphocyte Ratio With Recurrence and Mortality in Locally Advanced Non-Small Cell Lung Cancer.

ABSTRACT:

Objectives

Neutrophil-lymphocyte ratio (NLR) has been associated with mortality in non-small cell lung cancer (NSCLC), but its association with recurrence in locally advanced NSCLC (LA-NSCLC), specifically, is less established. We hypothesized pre- and posttreatment NLR would be associated with recurrence and mortality.

Methods

We studied the association of pretreatment NLR (pre-NLR) and posttreatment NLR at 1 (post-NLR₁) and 3 months (post-NLR₃) with outcomes in patients with LA-NSCLC treated with chemoradiation. Pre-NLR was dichotomized by 5, an a priori cutoff previously shown to be prognostic in LA-NSCLC. Post-NLR₁ and post-NLR₃ were dichotomized by their medians.

Results

We identified 135 patients treated with ch

SUBMITTER: Sebastian NT 

PROVIDER: S-EPMC7676908 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature