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Traces pilot pharmacokinetic study dataset.


ABSTRACT: The dataset displays the pharmacokinetics data obtained from the TRACES pilot study. The nine patients included were undergoing haemorrhagic caesarean section (blood loss > 800?mL) and receiving a single i.v dose of tranexamic acid (0.5, 1 or 2?g over 1 min). The dataset gathers the tranexamic acid blood and urinary concentrations. With these first elements, a pharmacokinetic compartment model was built as described in Gilliot et al. and the individual pharmacokinetic parameters were estimated. In parallel, the patients anthropometric, biological, and clinical characteristics were collected. The correlation between the patient data and the estimated individual pharmacokinetic parameters were tested. The correlation tests revealed that the dose, the height, the body weight, and the ideal bodyweight had and impact on the volume of distribution of tranexamic acid. According to these results, these latter covariates were explored using a multi-regression analysis in Gilliot et al.

SUBMITTER: Gilliot S 

PROVIDER: S-EPMC7677109 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Traces pilot pharmacokinetic study dataset.

Gilliot S S   Ducloy-Bouthors A S AS   Hennart B B   Loingeville F F   Jeanne M M   Lebuffe G G   Odou P P  

Data in brief 20201101


The dataset displays the pharmacokinetics data obtained from the TRACES pilot study. The nine patients included were undergoing haemorrhagic caesarean section (blood loss > 800 mL) and receiving a single i.v dose of tranexamic acid (0.5, 1 or 2 g over 1 min). The dataset gathers the tranexamic acid blood and urinary concentrations. With these first elements, a pharmacokinetic compartment model was built as described in Gilliot et al. and the individual pharmacokinetic parameters were estimated.  ...[more]

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