Mutant p53 in Cancer Progression and Targeted Therapies.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhu G
PROVIDER: S-EPMC7677253 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Mutant p53 in Cancer Progression and Targeted Therapies.
Zhu Gaoyang G Pan Chaoyun C Bei Jin-Xin JX Li Bo B Liang Chen C Xu Yang Y Fu Xuemei X
Frontiers in oncology 20201106
<i>TP53</i> is the most frequently mutated tumor suppressor gene in human cancer. The majority of mutations of p53 are missense mutations, leading to the expression of the full length p53 mutant proteins. Mutant p53 (Mutp53) proteins not only lose wild-type p53-dependent tumor suppressive functions, but also frequently acquire oncogenic gain-of-functions (GOF) that promote tumorigenesis. In this review, we summarize the recent advances in our understanding of the oncogenic GOF of mutp53 and the ...[more]
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