Dataset Information

Association of Genes Involved in the Metabolic Pathways of Amyloid-? and Tau Proteins With Sporadic Late-Onset Alzheimer's Disease in the Southern Han Chinese Population.

ABSTRACT: The genes involved in the metabolic pathways of amyloid-? (A?) and tau proteins significantly influence the etiology of Alzheimer's disease (AD). Various studies have explored the associations between some of these genes and AD in the Caucasian population; however, researches regarding these associations remain limited in the Chinese population. To systematically evaluate the associations of these genes with AD, we investigated 19 genes involved in the metabolism of A? and tau based on previous studies selected using the PubMed database. This study included 372 patients with sporadic late-onset AD (sLOAD) and 345 cognitively healthy individuals from southern China. The results were replicated in the International Genomics of Alzheimer's Project (IGAP). Protein-protein interactions were determined using the STRING v11 database. We found that a single-nucleotide polymorphism, rs11682128, of BIN1 conferred susceptibility to sLOAD after adjusting for age, sex, and APOE ?4 status and performing the Bonferroni correction {corrected P = 0.000153, odds ratio (OR) [95% confidence interval (CI)] = 1.403 (1.079-1.824)}, which was replicated in the IGAP. Protein-protein interactions indicated that BIN1 was correlated with MAPT. Moreover, rare variants of NEP and FERMT2 (0.0026 < corrected P < 0.05), and the A? degradation, tau pathology, and tau phosphatase pathways (0.01 < corrected P < 0.05), were nominally significantly associated with sLOAD. This study suggested that the genes involved in the metabolic pathways of A? and tau contributed to the etiology of sLOAD in the southern Han Chinese population.

SUBMITTER: Xiao X

PROVIDER: S-EPMC7677357 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Association of Genes Involved in the Metabolic Pathways of Amyloid-β and Tau Proteins With Sporadic Late-Onset Alzheimer's Disease in the Southern Han Chinese Population.

Xiao Xuewen X Jiao Bin B Liao Xinxin X Zhang Weiwei W Yuan Zhenhua Z Guo Lina L Wang Xin X Zhou Lu L Liu Xixi X Yan Xinxiang X Tang Beisha B Shen Lu L

Frontiers in aging neuroscience 20201106

The genes involved in the metabolic pathways of amyloid-β (Aβ) and tau proteins significantly influence the etiology of Alzheimer's disease (AD). Various studies have explored the associations between some of these genes and AD in the Caucasian population; however, researches regarding these associations remain limited in the Chinese population. To systematically evaluate the associations of these genes with AD, we investigated 19 genes involved in the metabolism of Aβ and tau based on previous ...[more]

PMID: 33240075

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Dataset Information

Association of Genes Involved in the Metabolic Pathways of Amyloid-? and Tau Proteins With Sporadic Late-Onset Alzheimer's Disease in the Southern Han Chinese Population.

Publications

Association of Genes Involved in the Metabolic Pathways of Amyloid-β and Tau Proteins With Sporadic Late-Onset Alzheimer's Disease in the Southern Han Chinese Population.

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