Unknown

Dataset Information

0

Potential Metabolic Biomarkers for Early Detection of Oral Lichen Planus, a Precancerous Lesion.


ABSTRACT: Background: Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory disorder and precancerous oral lesion with high incidence. The current diagnostic method of OLP is very limited and metabolomics may provide a new approach for quantitative evaluation. Methods: The Ultra-Performance Liquid Chromatography-Quadrupole/Orbitrap High Resolution Mass Spectrometry (UHPLC-Q-Orbitrap HRMS) was applied to analyze the change of metabolites in serum of patients with OLP. A total of 115 OLP patients and 124 healthy controls were assigned to either a training set (n = 160) or a test set (n = 79). The potential biomarkers and the change of serum metabolites were profiled and evaluated by multivariate analysis. Results: Totally, 23 differential metabolites were identified in the training set between OLP group and healthy group. Three prominent metabolites in receiver operating characteristic (ROC) were selected as a panel to distinguish OLP or healthy individuals in the test set, and the diagnostic accuracy was 86.1%. Conclusions: This study established a new method for the early detection of OLP by analyzing serum metabolomics using UHPLC-Q-Orbitrap HRMS, which will help in understanding the pathological processes of OLP and identifying precancerous lesions in oral cavity.

SUBMITTER: Wang XS 

PROVIDER: S-EPMC7677577 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Potential Metabolic Biomarkers for Early Detection of Oral Lichen Planus, a Precancerous Lesion.

Wang Xiao-Shuang XS   Sun Zhi Z   Liu Li-Wei LW   Du Qiu-Zheng QZ   Liu Zhang-Suo ZS   Yang Yan-Jie YJ   Xue Peng P   Zhao Hong-Yu HY  

Frontiers in pharmacology 20201106


<b>Background:</b> Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory disorder and precancerous oral lesion with high incidence. The current diagnostic method of OLP is very limited and metabolomics may provide a new approach for quantitative evaluation. <b>Methods:</b> The Ultra-Performance Liquid Chromatography-Quadrupole/Orbitrap High Resolution Mass Spectrometry (UHPLC-Q-Orbitrap HRMS) was applied to analyze the change of metabolites in serum of patients with OLP. A total of  ...[more]

Similar Datasets

| S-EPMC8898126 | biostudies-literature
| S-EPMC4565846 | biostudies-literature
| S-EPMC8560742 | biostudies-literature
| S-EPMC7738920 | biostudies-literature
| S-EPMC7428844 | biostudies-literature
| S-EPMC6479702 | biostudies-literature
| S-EPMC4785528 | biostudies-literature
| S-EPMC8466626 | biostudies-literature
| S-EPMC7943413 | biostudies-literature
| S-EPMC6889227 | biostudies-literature