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Clinical Characteristics and Prognosis of Gastric Cancer Patients with BRCA 1/2 Germline Mutations: Report of Ten Cases and a Literature Review.

ABSTRACT: Background:The prognosis of gastric cancer (GC) is poor with a median overall survival (OS) of less than 12 months in advanced-stage disease. The search for distinct genetic subgroups of GC patients and predictive biomarkers is ongoing. While BRCA1 or BRCA2 germline mutations (gBRCAm) have potential therapeutic implications in ovarian, breast and pancreatic cancers, their significance in GC patients has not been established. Patients and Methods:A retrospective multi-center data analysis of GC patients with gBRCAm was conducted, detailing the clinical characteristics and disease course in this unique subset of patients. Results:Ten GC patients with gBRCAm were identified, six of them with metastatic disease. The median OS of all ten GC patients was 47.5 (13-192) months. Median OS for patients diagnosed with operable disease was 55.5 (13-192) months and of the patients with metastatic disease (calculated from metastatic disease diagnosis) 32 (15-52) months with an exceptional 1-, 2- and 3-year survival rate of 100%, 83.3% and 50%, respectively. Conclusion:These preliminary data suggest that gBRCAm in GC patients are associated with a favorable prognosis. Furthermore, gBRCAm might be a predictive biomarker to DNA-damaging agents response in GC patients, similarly to its established role in other malignancies. Further research is needed to confirm our findings.

SUBMITTER: Halpern N

PROVIDER: S-EPMC7677647 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Clinical Characteristics and Prognosis of Gastric Cancer Patients with <i>BRCA 1/2</i> Germline Mutations: Report of Ten Cases and a Literature Review.

Halpern Naama N Grinshpun Albert A Boursi Ben B Golan Talia T Margalit Ofer O Aderka Dan D Friedman Eitan E Laitman Yael Y Hubert Ayala A Kadouri Luna L Hamburger Tamar T Barnes-Kedar Inbal I Levi Zohar Z Ben-Aharon Irit I Brenner Baruch B Goldberg Yael Y Peretz Tamar T Shacham-Shmueli Einat E

OncoTargets and therapy 20201113

<h4>Background</h4>The prognosis of gastric cancer (GC) is poor with a median overall survival (OS) of less than 12 months in advanced-stage disease. The search for distinct genetic subgroups of GC patients and predictive biomarkers is ongoing. While <i>BRCA1</i> or <i>BRCA2</i> germline mutations (gBRCAm) have potential therapeutic implications in ovarian, breast and pancreatic cancers, their significance in GC patients has not been established.<h4>Patients and methods</h4>A retrospective multi ...[more]

PMID: 33235458

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Dataset Information

Clinical Characteristics and Prognosis of Gastric Cancer Patients with BRCA 1/2 Germline Mutations: Report of Ten Cases and a Literature Review.

Publications

Clinical Characteristics and Prognosis of Gastric Cancer Patients with <i>BRCA 1/2</i> Germline Mutations: Report of Ten Cases and a Literature Review.

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