GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia.

ABSTRACT:

Background and purpose

Brain acidosis is prevalent in stroke and other neurological diseases. Acidosis can have paradoxical injurious and protective effects. The purpose of this study is to determine whether a proton receptor exists in neurons to counteract acidosis-induced injury.

Methods

We analyzed the expression of proton-sensitive GPCRs (G protein-coupled receptors) in the brain, examined acidosis-induced signaling in vitro, and studied neuronal injury using in vitro and in vivo mouse models.

Results

GPR68, a proton-sensitive GPCR, was present in both mouse and human brain, and elicited neuroprotection in acidotic and ischemic conditions. GPR68 exhibited wide expression in brain neurons and mediated acidosis-induced PKC (protein kinase C) activation. PKC inhibiti

SUBMITTER: Wang T 

PROVIDER: S-EPMC7678672 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature