Women's higher brain metabolic rate compensates for early Alzheimer's pathology.
Ontology highlight
ABSTRACT:
SUBMITTER: Sundermann EE
PROVIDER: S-EPMC7678742 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Women's higher brain metabolic rate compensates for early Alzheimer's pathology.
Sundermann Erin E EE Maki Pauline M PM Reddy Sarah S Bondi Mark W MW Biegon Anat A
Alzheimer's & dementia (Amsterdam, Netherlands) 20201120 1
<h4>Introduction</h4>The female advantage in brain metabolic function may confer cognitive resilience against Alzheimer's disease (AD).<h4>Methods</h4>A total of 1259 participants (44% women; 52% mild cognitive impairment; 18% AD) aged 55 to 90 from the Alzheimer's Disease Neuroimaging Initiative (ANDI) completed tests of global cognition, verbal memory, and executive function, and neuroimaging assessments of regional glucose metabolism, hippocampal volume (HV), and amyloid beta (Aβ). We examine ...[more]
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