Ontology highlight
ABSTRACT:
SUBMITTER: Moede T
PROVIDER: S-EPMC7678872 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Moede Tilo T Leibiger Barbara B Vaca Sanchez Pilar P Daré Elisabetta E Köhler Martin M Muhandiramlage Thusitha P TP Leibiger Ingo B IB Berggren Per-Olof PO
Scientific reports 20201119 1
The secretion of glucagon by pancreatic alpha cells is regulated by a number of external and intrinsic factors. While the electrophysiological processes linking a lowering of glucose concentrations to an increased glucagon release are well characterized, the evidence for the identity and function of the glucose sensor is still incomplete. In the present study we aimed to address two unsolved problems: (1) do individual alpha cells have the intrinsic capability to regulate glucagon secretion by g ...[more]