Ontology highlight
ABSTRACT:
SUBMITTER: Goyal A
PROVIDER: S-EPMC7679107 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Goyal Ashish A Cardozo-Ojeda E Fabian EF Schiffer Joshua T JT
Science advances 20201120 47
To affect the COVID-19 pandemic, lifesaving antiviral therapies must be identified. The number of clinical trials that can be performed is limited. We developed mathematical models to project multiple therapeutic approaches. Our models recapitulate off-treatment viral dynamics and predict a three-phase immune response. Simulated treatment with remdesivir, selinexor, neutralizing antibodies, or cellular immunotherapy demonstrates that rapid viral elimination is possible if in vivo potency is suff ...[more]