Ontology highlight
ABSTRACT:
SUBMITTER: Kargl D
PROVIDER: S-EPMC7679142 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kargl Dominic D Kaczanowska Joanna J Ulonska Sophia S Groessl Florian F Piszczek Lukasz L Lazovic Jelena J Buehler Katja K Haubensak Wulf W
eLife 20201120
Affective responses depend on assigning value to environmental predictors of threat or reward. Neuroanatomically, this affective value is encoded at both cortical and subcortical levels. However, the purpose of this distributed representation across functional hierarchies remains unclear. Using fMRI in mice, we mapped a discrete cortico-limbic loop between insular cortex (IC), central amygdala (CE), and nucleus basalis of Meynert (NBM), which decomposes the affective value of a conditioned stimu ...[more]