Ontology highlight
ABSTRACT:
SUBMITTER: Li N
PROVIDER: S-EPMC7679242 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Li Ning N Bai Yifan Y Zhou Guangwei G Ma Ye Y Tan Mengwei M Qiao Fan F Li Xin X Shen Ming M Song Xiaowei X Zhao Xianxian X Liu Xiaohong X Xu Zhiyun Z
Molecular therapy. Nucleic acids 20201015
Calcific aortic valve disease (CAVD) is a common heart valve disease in aging populations, and aberrant osteogenic differentiation of valvular interstitial cells (VICs) plays a critical role in the pathogenesis of ectopic ossification of the aortic valve. miR-214 has been validated to be involved in the osteogenesis process. Here, we aim to investigate the role and mechanism of miR-214 in CAVD progression. miR-214 expression was significantly downregulated in CAVD aortic valve leaflets, accompan ...[more]