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Robust alternative to the righting reflex to assess arousal in rodents.

ABSTRACT: The righting reflex (RR) is frequently used to assess level of arousal and applied to animal models of a range of neurological disorders. RR produces a binary result that, when positive, is used to infer restoration of consciousness, often without further behavioral corroboration. We find that RR is an unreliable metric for arousal/recovery of consciousness. Instead, cortical activity and motor behavior that accompany RR are a non-binary, superior criterion that accurately calibrates and establishes level of arousal in rodents.

SUBMITTER: Gao S

PROVIDER: S-EPMC7679463 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Robust alternative to the righting reflex to assess arousal in rodents.

Gao Sijia S Calderon Diany Paola DP

Scientific reports 20201120 1

The righting reflex (RR) is frequently used to assess level of arousal and applied to animal models of a range of neurological disorders. RR produces a binary result that, when positive, is used to infer restoration of consciousness, often without further behavioral corroboration. We find that RR is an unreliable metric for arousal/recovery of consciousness. Instead, cortical activity and motor behavior that accompany RR are a non-binary, superior criterion that accurately calibrates and establi ...[more]

PMID: 33219247

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