Ontology highlight
ABSTRACT:
SUBMITTER: Arabi SH
PROVIDER: S-EPMC7679958 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Arabi Seyed Hamidreza SH Aghelnejad Behdad B Volmer Jonas J Hinderberger Dariush D
Protein science : a publication of the Protein Society 20201022 12
We demonstrate that a molten globule-like (MG) state of a protein, usually described as a compact yet non-folded conformation that is only present in a narrow and delicate parameter range, is preserved in the high concentration environment of the protein hydrogel. We reveal mainly by means of electron paramagnetic resonance (EPR) spectroscopy that bovine serum albumin (BSA) retains the known basic MG state after a hydrogel has been formed from 20 wt% precursor solutions. At pH values of ~11.4, B ...[more]