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Recent progresses in marine microbial-derived antiviral natural products.

ABSTRACT: Viruses have always been a class of pathogenic microorganisms that threaten the health and safety of human life worldwide. However, for a long time, the treatment of viral infections has been slow to develop, and only a few antiviral drugs have been using clinically. Compared with these from terrestrial environments, marine-derived microorganisms can produce active substances with more novel structures and unique functions. From 2015 to 2019, 89 antiviral compounds of 8 structural classes have been isolated from marine microorganisms, of which 35 exhibit anti-H1N1 activity. This review surveys systematically marine microbial-derived natural products with antiviral activity and illustrates the impact of these compounds on antiviral drug discovery research.

SUBMITTER: Teng YF

PROVIDER: S-EPMC7680217 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Recent progresses in marine microbial-derived antiviral natural products.

Teng Yun-Fei YF Xu Li L Wei Mei-Yan MY Wang Chang-Yun CY Gu Yu-Cheng YC Shao Chang-Lun CL

Archives of pharmacal research 20201121 12

Viruses have always been a class of pathogenic microorganisms that threaten the health and safety of human life worldwide. However, for a long time, the treatment of viral infections has been slow to develop, and only a few antiviral drugs have been using clinically. Compared with these from terrestrial environments, marine-derived microorganisms can produce active substances with more novel structures and unique functions. From 2015 to 2019, 89 antiviral compounds of 8 structural classes have b ...[more]

PMID: 33222073

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