MicroRNA-146a controls age-related bone loss.
Ontology highlight
ABSTRACT:
SUBMITTER: Saferding V
PROVIDER: S-EPMC7681058 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
microRNA-146a controls age-related bone loss.
Saferding Victoria V Hofmann Melanie M Brunner Julia S JS Niederreiter Birgit B Timmen Melanie M Magilnick Nathaniel N Hayer Silvia S Heller Gerwin G Steiner Günter G Stange Richard R Boldin Mark M Schabbauer Gernot G Weigl Moritz M Hackl Matthias M Grillari Johannes J Smolen Josef S JS Blüml Stephan S
Aging cell 20201021 11
Bone loss is one of the consequences of aging, leading to diseases such as osteoporosis and increased susceptibility to fragility fractures and therefore considerable morbidity and mortality in humans. Here, we identify microRNA-146a (miR-146a) as an essential epigenetic switch controlling bone loss with age. Mice deficient in miR-146a show regular development of their skeleton. However, while WT mice start to lose bone with age, animals deficient in miR-146a continue to accrue bone throughout t ...[more]
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