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Vascular homeostasis at high-altitude: role of genetic variants and transcription factors.

ABSTRACT: High-altitude pulmonary edema occurs most frequently in non-acclimatized low landers on exposure to altitude ?2500?m. High-altitude pulmonary edema is a complex condition that involves perturbation of signaling pathways in vasoconstrictors, vasodilators, anti-diuretics, and vascular growth factors. Genetic variations are instrumental in regulating these pathways and evidence is accumulating for a role of epigenetic modification in hypoxic responses. This review focuses on the crosstalk between high-altitude pulmonary edema-associated genetic variants and transcription factors, comparing high-altitude adapted and high-altitude pulmonary edema-afflicted subjects. This approach might ultimately yield biomarker information both to understand and to design therapies for high-altitude adaptation.

SUBMITTER: Chanana N

PROVIDER: S-EPMC7682230 | biostudies-literature | 2020 Oct-Dec

REPOSITORIES: biostudies-literature

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Vascular homeostasis at high-altitude: role of genetic variants and transcription factors.

Chanana Neha N Palmo Tsering T Newman John H JH Pasha M A Qadar MAQ

Pulmonary circulation 20201001 4

High-altitude pulmonary edema occurs most frequently in non-acclimatized low landers on exposure to altitude ≥2500 m. High-altitude pulmonary edema is a complex condition that involves perturbation of signaling pathways in vasoconstrictors, vasodilators, anti-diuretics, and vascular growth factors. Genetic variations are instrumental in regulating these pathways and evidence is accumulating for a role of epigenetic modification in hypoxic responses. This review focuses on the crosstalk between h ...[more]

PMID: 33282179

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