Ontology highlight
ABSTRACT:
SUBMITTER: Baruch A
PROVIDER: S-EPMC7682391 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Baruch Amos A Wong Chin C Chinn Leslie W LW Vaze Anjali A Sonoda Junichiro J Gelzleichter Thomas T Chen Shan S Lewin-Koh Nicholas N Morrow Linda L Dheerendra Suresh S Boismenu Richard R Gutierrez Johnny J Wakshull Eric E Wilson Maria E ME Arora Puneet S PS
Proceedings of the National Academy of Sciences of the United States of America 20201102 46
Fibroblast growth factor 21 (FGF21) controls metabolic organ homeostasis and eating/drinking behavior via FGF receptor 1/Klothoβ (FGFR1/KLB) complexes expressed in adipocytes, pancreatic acinar cells, and the nervous system in mice. Chronic administration of recombinant FGF21 or engineered variants improves metabolic health in rodents, nonhuman primates, and humans; however, the rapid turnover of these molecules limits therapeutic utility. Here we show that the bispecific anti-FGFR1/KLB agonist ...[more]