Cortical microstructure in the amyotrophic lateral sclerosis-frontotemporal dementia continuum.

ABSTRACT:

Objective

To characterize the cortical macrostructure and microstructure of behavioral and cognitive changes along the amyotrophic lateral sclerosis (ALS)-frontotemporal dementia (FTD) continuum.

Methods

We prospectively recruited 88 participants with a 3T MRI structural and diffusion-weighted imaging sequences: 31 with ALS, 20 with the behavioral variant of FTD (bvFTD), and 37 cognitively normal controls. Participants with ALS underwent a comprehensive cognitive and behavioral assessment and were dichotomized into ALS without cognitive or behavioral impairment (ALSno-cbi; n = 12) and ALS with cognitive or behavioral impairment (ALScbi; n = 19). We computed cortical thickness and cortical mean diffusivity using a surface-based approach and explored the cortical correlates of

SUBMITTER: Illan-Gala I 

PROVIDER: S-EPMC7682829 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature