Ontology highlight
ABSTRACT:
SUBMITTER: Tang R
PROVIDER: S-EPMC7682987 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Tang Rui R Murray Christopher W CW Linde Ian L IL Kramer Nicholas J NJ Lyu Zhonglin Z Tsai Min K MK Chen Leo C LC Cai Hongchen H Gitler Aaron D AD Engleman Edgar E Lee Wonjae W Winslow Monte M MM
eLife 20201007
Cell-cell interactions influence all aspects of development, homeostasis, and disease. In cancer, interactions between cancer cells and stromal cells play a major role in nearly every step of carcinogenesis. Thus, the ability to record cell-cell interactions would facilitate mechanistic delineation of the role of the cancer microenvironment. Here, we describe GFP-based Touching Nexus (G-baToN) which relies upon nanobody-directed fluorescent protein transfer to enable sensitive and specific label ...[more]