Dataset Information

White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial.

ABSTRACT: Background: Early pathological changes in white matter microstructure can be studied using the diffusion tensor imaging (DTI). It is not only important to study these subtle pathological changes leading to cognitive decline, but also to ascertain how an intervention would impact the white matter microstructure and cognition in persons at-risk of dementia.

Objectives: To study the impact of a multidomain lifestyle intervention on white matter and cognitive changes during the 2-year Finnish Geriatric Intervention Study to prevent Cognitive Impairment and Disability (FINGER), a randomized controlled trial in at-risk older individuals (age 60-77 years) from the general population.

Methods: This exploratory study consisted of a subsample of 60 FINGER participants. Participants were randomized to either a multidomain intervention (diet, exercise, cognitive training, and vascular risk management, n?=?34) or control group (general health advice, n?=?26). All underwent baseline and 2-year brain DTI. Changes in fractional anisotropy (FA), diffusivity along domain (F1) and non-domain (F2) diffusion orientations, mean diffusivity (MD), axial diffusivity (AxD), radial diffusivity (RD), and their correlations with cognitive changes during the 2-year multidomain intervention were analyzed.

Results: FA decreased, and cognition improved more in the intervention group compared to the control group (p?
Conclusion: The 2-year multidomain FINGER intervention may modulate white matter microstructural alterations.

SUBMITTER: Stephen R

PROVIDER: S-EPMC7683078 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial.

Stephen Ruth R Solomon Alina A Ngandu Tiia T Levälahti Esko E Rinne Juha O JO Kemppainen Nina N Parkkola Riitta R Antikainen Riitta R Strandberg Timo T Kivipelto Miia M Soininen Hilkka H Liu Yawu Y

Journal of Alzheimer's disease : JAD 20200101 1

<h4>Background</h4>Early pathological changes in white matter microstructure can be studied using the diffusion tensor imaging (DTI). It is not only important to study these subtle pathological changes leading to cognitive decline, but also to ascertain how an intervention would impact the white matter microstructure and cognition in persons at-risk of dementia.<h4>Objectives</h4>To study the impact of a multidomain lifestyle intervention on white matter and cognitive changes during the 2-year F ...[more]

PMID: 32925045

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Project description:BACKGROUND:White matter alterations have been observed in patients with migraine. However, no microstructural white matter alterations have been found particularly in episodic or chronic migraine patients, and there is limited research focused on the comparison between these two groups of migraine patients. METHODS:Fifty-one healthy controls, 55 episodic migraine patients and 57 chronic migraine patients were recruited and underwent brain T1-weighted and diffusion-weighted MRI acquisition. Using Tract-Based Spatial Statistics (TBSS), fractional anisotropy, mean diffusivity, radial diffusivity and axial diffusivity were compared between the different groups. On the one hand, all migraine patients were compared against healthy controls. On the other hand, patients from each migraine group were compared between them and also against healthy controls. Correlation analysis between clinical features (duration of migraine in years, time from onset of chronic migraine in months, where applicable, and headache and migraine frequency, where applicable) and Diffusion Tensor Imaging measures was performed. RESULTS:Fifty healthy controls, 54 episodic migraine and 56 chronic migraine patients were finally included in the analysis. Significant decreased axial diffusivity (p?<?.05 false discovery rate and by number of contrasts corrected) was found in chronic migraine compared to episodic migraine in 38 white matter regions from the Johns Hopkins University ICBM-DTI-81 White-Matter Atlas. Significant positive correlation was found between time from onset of chronic migraine and mean fractional anisotropy in the bilateral external capsule, and negative correlation between time from onset of chronic migraine and mean radial diffusivity in the bilateral external capsule. CONCLUSIONS:These findings suggest global white matter structural differences between episodic migraine and chronic migraine. Patients with chronic migraine could present axonal integrity impairment in the first months of chronic migraine with respect to episodic migraine patients. White matter changes after the onset of chronic migraine might reflect a set of maladaptive plastic changes.

Dataset Information

White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial.

Publications

White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial.

Similar Datasets

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