Renal function is associated with blood neurofilament light chain level in older adults.
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ABSTRACT:
SUBMITTER: Akamine S
PROVIDER: S-EPMC7683708 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Renal function is associated with blood neurofilament light chain level in older adults.
Akamine Shoshin S Marutani Noriko N Kanayama Daisuke D Gotoh Shiho S Maruyama Riki R Yanagida Kanta K Sakagami Yukako Y Mori Kohji K Adachi Hiroyoshi H Kozawa Junji J Maeda Norikazu N Otsuki Michio M Matsuoka Takaaki T Iwahashi Hiromi H Shimomura Iichiro I Ikeda Manabu M Kudo Takashi T
Scientific reports 20201123 1
Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n = 43, serum NfL) and patients with diabetes mellitus (n = 18 ...[more]
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| S-EPMC8436486 | biostudies-literature
Project description:ObjectiveSerum neurofilament light chain (sNfL) is increasingly used as a neuroaxonal injury biomarker in the elderly. Besides age, little is known about how other physiological factors like renal function and body mass index (BMI) alter its levels. Here, we investigated the association of estimated glomerular filtration rate (eGFR) and BMI with sNfL in a large sample of elderly patients with atrial fibrillation (AF).MethodsThis is a cross-sectional analysis from the Swiss-AF Cohort (NCT02105844). We measured sNfL using an ultrasensitive single-molecule array assay. We calculated eGFR using the chronic kidney disease epidemiology collaboration (CKD-EPI) creatinine (eGFRcrea) and creatinine-cystatin C (eGFRcrea-cys) formulas, and BMI from weight and height measurements. We evaluated the role of eGFR and BMI as determinants of sNfL levels using multivariable linear regression and the adjusted R2 (R2 adj).ResultsAmong 2,277 Swiss-AF participants (mean age 73.3 years), eGFRcrea showed an inverse curvilinear association with sNfL after adjustment for age and cardiovascular comorbidities. BMI also showed an independent, inverse linear association with sNfL. The R2 adj of models with age, eGFRcrea, and BMI alone was 0.26, 0.35, and 0.02, respectively. A model with age and eGFRcrea combined explained 45% of the sNfL variance. Sensitivity analyses (i) further adjusting for vascular brain lesions (N = 1,402 participants with MRI) and (ii) using eGFRcrea-cys yielded consistent results.InterpretationIn an elderly AF cohort, both renal function and BMI were associated with sNfL, but only renal function explained a substantial proportion of the sNfL variance. This should be taken into account when using sNfL in elderly patients or patients with cardiovascular disease.
| S-EPMC9047720 | biostudies-literature