Renal function is associated with blood neurofilament light chain level in older adults.
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ABSTRACT:
SUBMITTER: Akamine S
PROVIDER: S-EPMC7683708 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Renal function is associated with blood neurofilament light chain level in older adults.
Akamine Shoshin S Marutani Noriko N Kanayama Daisuke D Gotoh Shiho S Maruyama Riki R Yanagida Kanta K Sakagami Yukako Y Mori Kohji K Adachi Hiroyoshi H Kozawa Junji J Maeda Norikazu N Otsuki Michio M Matsuoka Takaaki T Iwahashi Hiromi H Shimomura Iichiro I Ikeda Manabu M Kudo Takashi T
Scientific reports 20201123 1
Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n = 43, serum NfL) and patients with diabetes mellitus (n = 18 ...[more]
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