Dataset Information

Direct comparison of brain [¹⁸F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies.

ABSTRACT:

Background

Silicon photomultiplier-positron emission tomography (SiPM-PET) has better sensitivity, spatial resolution, and timing resolution than photomultiplier tube (PMT)-PET. The present study aimed to clarify the advantages of SiPM-PET in ¹⁸F-fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) brain imaging in a head-to-head comparison with PMT-PET in phantom and clinical studies.

Methods

Contrast was calculated from images acquired from a Hoffman 3D brain phantom, and image noise and uniformity were calculated from images acquired from a pool phantom using SiPM- and PMT-PET. Sequential PMT-PET and SiPM-PET [¹⁸F]FDG images were acquired over a period of 10 min from 22 controls and 10 patients. All images were separately normalized to a standard [¹⁸F]FDG PET template, then the mean standardized uptake values (SUV_mean) and Z-score were calculated using MIMneuro and CortexID Suite, respectively.

Results

Image contrast, image noise, and uniformity in SiPM-PET changed 19.2, 3.5, and -?40.0% from PMT-PET, respectively. These physical indices of both PET scanners satisfied the criteria for acceptable image quality published by the Japanese Society of Nuclear Medicine of contrast >?55%, CV ? 15%, and SD ? 0.0249, respectively. Contrast was 70.0% for SiPM-PET without TOF and 59.5% for PMT-PET without TOF. The TOF improved contrast by 3.5% in SiPM-PET. The SUV_mean using SiPM-PET was significantly higher than PMT-PET and did not correlate with a time delay. Z-scores were also significantly higher in images acquired from SiPM-PET (except for the bilateral posterior cingulate) than PMT-PET because the peak signal that was extracted by the calculation of Z-score in CortexID Suite was increased. The hypometabolic area in statistical maps was reduced and localized using SiPM-PET. The trend was independent of whether the images were derived from controls or patients.

Conclusions

The improved spatial resolution and sensitivity of SiPM-PET contributed to better image contrast and uniformity in brain [¹⁸F]FDG images. The SiPM-PET offers better quality and more accurate quantitation of brain PET images. The SUV_mean and Z-scores were higher in SiPM-PET than PMT-PET due to improved PVE. [¹⁸F]FDG images acquired using SiPM-PET will help to improve diagnostic outcomes based on statistical image analysis because SiPM-PET would localize the distribution of glucose metabolism on Z-score maps.

SUBMITTER: Wagatsuma K

PROVIDER: S-EPMC7683764 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Direct comparison of brain [<sup>18</sup>F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies.

Wagatsuma Kei K Sakata Muneyuki M Ishibashi Kenji K Hirayama Akira A Kawakami Hirofumi H Miwa Kenta K Suzuki Yukihisa Y Ishii Kenji K

EJNMMI physics 20201123 1

<h4>Background</h4>Silicon photomultiplier-positron emission tomography (SiPM-PET) has better sensitivity, spatial resolution, and timing resolution than photomultiplier tube (PMT)-PET. The present study aimed to clarify the advantages of SiPM-PET in <sup>18</sup>F-fluoro-2-deoxy-D-glucose ([<sup>18</sup>F]FDG) brain imaging in a head-to-head comparison with PMT-PET in phantom and clinical studies.<h4>Methods</h4>Contrast was calculated from images acquired from a Hoffman 3D brain phantom, and i ...[more]

PMID: 33226451

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Dataset Information

Direct comparison of brain [¹⁸F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies.

Background

Methods

Results

Conclusions

Publications

Direct comparison of brain [<sup>18</sup>F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Direct comparison of brain [18F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies.

Background

Methods

Results

Conclusions

Publications

Direct comparison of brain [<sup>18</sup>F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Direct comparison of brain [¹⁸F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies.