Sorafenib for treating head and neck adenocarcinoma of unknown primary site: a case report.
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SUBMITTER: Chen J
PROVIDER: S-EPMC7683926 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Sorafenib for treating head and neck adenocarcinoma of unknown primary site: a case report.
Chen Jingxian J Cheng Chien-Shan CS Chen Jie J Lv Lingling L Shen Xiaoheng X Zheng Lan L Zheng Lan L
The Journal of international medical research 20201101 11
The aim of the present study was to report a rare case of head and neck adenocarcinoma with an unknown primary site in a 59-year-old man. After disease progression followed by multiple cycles of chemotherapy and radiotherapy, genetic screening using next-generation sequencing identified vascular endothelial growth factor A amplification and the TP53 R209Kfs mutation. Treatment with the multi-targeted protein kinase inhibitor sorafenib controlled the patient's symptoms and improved his quality of ...[more]
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