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Gamma oscillations predict pro-cognitive and clinical response to auditory-based cognitive training in schizophrenia.


ABSTRACT: Cognitive impairments are pervasive and disabling features of schizophrenia. Targeted cognitive training (TCT) is a "bottom-up" cognitive remediation intervention with efficacy for neurocognitive outcomes in schizophrenia, yet individual responses are variable. Gamma oscillatory measures are leading candidate biomarkers in the development of biologically informed pro-cognitive therapeutics. Forty-two schizophrenia patients were recruited from a long-term residential treatment facility. Participants were randomized to receive either 1?h of cognitive training (TCT, n?=?21) or computer games (TAU, n?=?21). All participants received standard-of-care treatment; the TCT group additionally completed 30 h of cognitive training. The auditory steady-state response paradigm was used to elicit gamma oscillatory power and synchrony during electroencephalogram recordings. Detailed clinical and cognitive assessments were collected at baseline and after completion of the study. Baseline gamma power predicted cognitive gains after a full course of TCT (MCCB, R2?=?0.31). A change in gamma power after 1-h TCT exposure predicted improvement in both positive (SAPS, R2?=?0.40) and negative (SANS, R2?=?0.30) symptoms. These relationships were not observed in the TAU group (MCCB, SAPS, and SANS, all R2?

SUBMITTER: Molina JL 

PROVIDER: S-EPMC7684295 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Gamma oscillations predict pro-cognitive and clinical response to auditory-based cognitive training in schizophrenia.

Molina Juan L JL   Thomas Michael L ML   Joshi Yash B YB   Hochberger William C WC   Koshiyama Daisuke D   Nungaray John A JA   Cardoso Lauren L   Sprock Joyce J   Braff David L DL   Swerdlow Neal R NR   Light Gregory A GA  

Translational psychiatry 20201123 1


Cognitive impairments are pervasive and disabling features of schizophrenia. Targeted cognitive training (TCT) is a "bottom-up" cognitive remediation intervention with efficacy for neurocognitive outcomes in schizophrenia, yet individual responses are variable. Gamma oscillatory measures are leading candidate biomarkers in the development of biologically informed pro-cognitive therapeutics. Forty-two schizophrenia patients were recruited from a long-term residential treatment facility. Participa  ...[more]

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