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ABSTRACT:
SUBMITTER: Rodstein I
PROVIDER: S-EPMC7684579 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Rodstein Ilja I Prendes Daniel Sowa DS Wickert Leon L Paaßen Maurice M Gessner Viktoria H VH
The Journal of organic chemistry 20200921 22
Ylide-substituted phosphines have been shown to be excellent ligands for C-N coupling reactions under mild reaction conditions. Here we report studies on the impact of the steric demand of the substituent in the ylide-backbone on the catalytic activity. Two new YPhos ligands with bulky <i>ortho</i>-tolyl (pinkYPhos) and mesityl (mesYPhos) substituents were synthesized, which are slightly more sterically demanding than their phenyl analogue but considerably less flexible. This change in the ligan ...[more]