Incidence of Huntington disease in a northeastern Spanish region: a 13-year retrospective study at tertiary care centre.

ABSTRACT:

Background

Despite the progress in the knowledge of Huntington disease (HD) in recent years, the epidemiology continues uncertain, so the study of incidence becomes relevant. This is important since various factors (type of population, diagnostic criteria, disease-modifying factors, etc.) make these data highly variable. Therefore, the genetic diagnosis of these patients is important, since it unequivocally allows the detection of new cases.

Methods

Descriptive retrospective study with 179 individuals. Incidence of HD was calculated from the ratio of number of symptomatic cases newly diagnosed per 100,000 inhabitants per year during the period 2007-2019 in Aragon (Spain).

Results

50 (27.9%) incident cases of HD (CAG repeat length ≥ 36) were identified from a total of

SUBMITTER: Sienes Bailo P 

PROVIDER: S-EPMC7684714 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature