Ontology highlight
ABSTRACT:
SUBMITTER: Gijzen L
PROVIDER: S-EPMC7684793 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Gijzen Linda L Marescotti Diego D Raineri Elisa E Nicolas Arnaud A Lanz Henriette L HL Guerrera Diego D van Vught Remko R Joore Jos J Vulto Paul P Peitsch Manuel C MC Hoeng Julia J Lo Sasso Giuseppe G Kurek Dorota D
SLAS technology 20200624 6
Development of efficient drugs and therapies for the treatment of inflammatory conditions in the intestine is often hampered by the lack of reliable, robust, and high-throughput in vitro and in vivo models. Current models generally fail to recapitulate key aspects of the intestine, resulting in low translatability to the human situation. Here, an immunocompetent 3D perfused intestine-on-a-chip platform was developed and characterized for studying intestinal inflammation. Forty independent polari ...[more]