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Pharmacist-led counselling intervention to improve antiretroviral drug adherence in Pakistan: a randomized controlled trial.


ABSTRACT: BACKGROUND:Pakistan is facing a growing population of people living with human immunodeficiency (HIV). In this randomized controlled trial, we investigate if a pharmacist-led intervention can increase adherence to antiretroviral therapy (ART) for people living with HIV (PLWH). METHODS:Adults with HIV, who have been taking ART for more than 3?months were randomly assigned to receive either a pharmacist-led intervention or their usual care. Measures of adherence were collected at 1) baseline 2) just prior to delivery of intervention and 3) 8 weeks later. The primary outcomes were CD4 cell count and self-reported adherence measured with the AIDS Clinical Trial Group (ACTG) questionnaire. RESULTS:Post-intervention, the intervention group showed a statistically significant increase in CD4 cell counts as compared to the usual care group (p?=?0.0054). In addition, adherence improved in the intervention group, with participants being 5.96 times more likely to report having not missed their medication for longer periods of time (p?=?0.0086) while participants in the intervention group were 7.74 times more likely to report missing their ART less frequently (p?

SUBMITTER: Chatha ZF 

PROVIDER: S-EPMC7684945 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Pharmacist-led counselling intervention to improve antiretroviral drug adherence in Pakistan: a randomized controlled trial.

Chatha Zeenat Fatima ZF   Rashid Usman U   Olsen Sharon S   Din Fakhar Ud FU   Khan Amjad A   Nawaz Komal K   Gan Siew Hua SH   Khan Gul Majid GM  

BMC infectious diseases 20201123 1


<h4>Background</h4>Pakistan is facing a growing population of people living with human immunodeficiency (HIV). In this randomized controlled trial, we investigate if a pharmacist-led intervention can increase adherence to antiretroviral therapy (ART) for people living with HIV (PLWH).<h4>Methods</h4>Adults with HIV, who have been taking ART for more than 3 months were randomly assigned to receive either a pharmacist-led intervention or their usual care. Measures of adherence were collected at 1)  ...[more]

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