Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC7685079 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Zhang Yue Y Cheng Shaoqiang S Zhang Guoqiang G Ma Wenjie W Liu Yang Y Zhao Rui R Zhang Qingyuan Q Pang Da D
Cancer science 20120419 6
Expression cloning was used to initially isolate the reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene as a suppressor of transformation. The gene was found to encode a membrane-anchored regulator of MMPs. Experimental studies showed that RECK can suppress tumor invasion, metastasis, and angiogenesis. However, the clinical impact of RECK remains unclear. To assess the clinical significance of RECK expression in invasive breast cancer, a total of 119 patients with invasive br ...[more]