Ontology highlight
ABSTRACT:
SUBMITTER: Carbone S
PROVIDER: S-EPMC7685099 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Carbone Salvatore S Billingsley Hayley E HE Canada Justin M JM Bressi Edoardo E Rotelli Brando B Kadariya Dinesh D Dixon Dave L DL Markley Roshanak R Trankle Cory R CR Cooke Richard R Rao Krishnasree K B Shah Keyur K Medina de Chazal Horacio H Chiabrando Juan Guido JG Vecchié Alessandra A Dell Megan M L Mihalick Virginia V Bogaev Roberta R Hart Linda L Van Tassell Benjamin W BW Arena Ross R Celi Francesco S FS Abbate Antonio A
Diabetes/metabolism research and reviews 20200615 8
<h4>Background</h4>Canagliflozin reduces hospitalizations for heart failure (HF) in type 2 diabetes mellitus (T2DM). Its effect on cardiorespiratory fitness and cardiac function in patients with established HF with reduced ejection fraction (HFrEF) is unknown.<h4>Methods</h4>We conducted a double-blind randomized controlled trial of canagliflozin 100 mg or sitagliptin 100 mg daily for 12 weeks in 88 patients, and measured peak oxygen consumption (VO<sub>2</sub> ) and minute ventilation/carbon di ...[more]